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Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $39 | In Stock | |
5 mg | $64 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $198 | In Stock | |
50 mg | $372 | In Stock | |
100 mg | $556 | In Stock | |
500 mg | $1,220 | In Stock | |
1 mL x 10 mM (in DMSO) | $70 | In Stock |
Description | Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity. |
Targets&IC50 | REH cells:0.44 μM, MOLM-13:0.33 μM, OCI-AML3 cells:0.24 μM, NALM6:0.32 μM |
In vitro | In both solid and ALL transplant tumor models, oral administration of JNJ-26854165 (20 mg/kg) significantly altered EFS distribution. |
In vivo | In leukemia cell lines, JNJ-26854165 inhibits cell growth and induces apoptosis, demonstrating inhibitory effects on OCI-AML-3 (IC50=0.24 μM), MOLM-13 (IC50=0.33 μM), NALM-6 (IC50=0.32 μM), and REH (IC50=0.44 μM). Additionally, it inhibits cell proliferation in various human cancer cell lines (H460, A549, p53-WT-HCT116, and p53-null-HCT116). |
Cell Research | Cell lines are maintained in RPMI 1640 medium containing 10% heat-inactivated fetal calf serum (FCS). OCI-AML-3, MOLM-13, NB4 and U937 cells are derived from acute myelogenous leukemia (AML) patients, K562 from a chronic myelogenous leukemia (CML) patient in blast crisis, and NALM-6, REH, P12-ICHIK(Only for Reference) |
Alias | JNJ-26854165 |
Molecular Weight | 328.41 |
Formula | C21H20N4 |
Cas No. | 881202-45-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 2 mg/mL (6.08 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 50 mg/mL (152.25 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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