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Serdemetan

Catalog No. T2243Cas No. 881202-45-5
Alias JNJ-26854165

Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.

Serdemetan

Serdemetan

Purity: 98.18%
Catalog No. T2243Alias JNJ-26854165Cas No. 881202-45-5
Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
Pack SizePriceAvailabilityQuantity
2 mg$39In Stock
5 mg$64In Stock
10 mg$97In Stock
25 mg$198In Stock
50 mg$372In Stock
100 mg$556In Stock
500 mg$1,220In Stock
1 mL x 10 mM (in DMSO)$70In Stock
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Purity:98.18%
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Product Introduction

Bioactivity
Description
Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
Targets&IC50
REH cells:0.44 μM, MOLM-13:0.33 μM, OCI-AML3 cells:0.24 μM, NALM6:0.32 μM
In vitro
In both solid and ALL transplant tumor models, oral administration of JNJ-26854165 (20 mg/kg) significantly altered EFS distribution.
In vivo
In leukemia cell lines, JNJ-26854165 inhibits cell growth and induces apoptosis, demonstrating inhibitory effects on OCI-AML-3 (IC50=0.24 μM), MOLM-13 (IC50=0.33 μM), NALM-6 (IC50=0.32 μM), and REH (IC50=0.44 μM). Additionally, it inhibits cell proliferation in various human cancer cell lines (H460, A549, p53-WT-HCT116, and p53-null-HCT116).
Cell Research
Cell lines are maintained in RPMI 1640 medium containing 10% heat-inactivated fetal calf serum (FCS). OCI-AML-3, MOLM-13, NB4 and U937 cells are derived from acute myelogenous leukemia (AML) patients, K562 from a chronic myelogenous leukemia (CML) patient in blast crisis, and NALM-6, REH, P12-ICHIK(Only for Reference)
AliasJNJ-26854165
Chemical Properties
Molecular Weight328.41
FormulaC21H20N4
Cas No.881202-45-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 2 mg/mL (6.08 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 50 mg/mL (152.25 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.0450 mL15.2249 mL30.4497 mL152.2487 mL
5 mM0.6090 mL3.0450 mL6.0899 mL30.4497 mL
DMSO
1mg5mg10mg50mg
10 mM0.3045 mL1.5225 mL3.0450 mL15.2249 mL
20 mM0.1522 mL0.7612 mL1.5225 mL7.6124 mL
50 mM0.0609 mL0.3045 mL0.6090 mL3.0450 mL
100 mM0.0304 mL0.1522 mL0.3045 mL1.5225 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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