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CP-31398 dihydrochloride

CP-31398 dihydrochloride
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Purity:99.53%
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CP-31398 dihydrochloride

Catalog No. T21648Cas No. 1217195-61-3
CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
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Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
2 mg$44In Stock
5 mg$70In Stock
10 mg$116In Stock
25 mg$226In Stock
50 mg$363In Stock
100 mg$593In Stock
200 mg$843In Stock
500 mg$1,250In Stock
1 mL x 10 mM (in DMSO)$88In Stock
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Product Introduction

Bioactivity
Description
CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
In vitro
CP-31398 (15 μg/mL, 20 hours) could induce apoptosis and cell cycle arrest in SW480 cells[1]. CP-31398 (36.75 μM, 16 h) induces p21 in p53-mutant cells[2].
AliasCP 31398 dihydrochloride
Chemical Properties
Molecular Weight435.4
FormulaC22H28Cl2N4O
Cas No.1217195-61-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 6 mg/ml (13.78 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2967 mL11.4837 mL22.9674 mL114.8369 mL
5 mM0.4593 mL2.2967 mL4.5935 mL22.9674 mL
10 mM0.2297 mL1.1484 mL2.2967 mL11.4837 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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