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(-)-Curine
Catalog No. TN1156Cas No. 436-05-5
(-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status.
(-)-Curine
Catalog No. TN1156Cas No. 436-05-5
(-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $190 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $210 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | (-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status. |
| In vitro | As in many other cancers, p53 mutations are commonly observed in HCCs (Hussain et al., 2007; Levine et al., 1994) [1,2]. Tumor tissues with mutant p53 seems to be more aggressive and resist to chemotherapy than that harboring wide-type p53 (Harris and Hollstein, 1994; Parrales and Iwakuma, 2015) [3,4]. (-)-Curine, a novel bisbenzylisoquinoline alkaloid, is one of the main components isolated from the roots of Cyclea wattii. Here, it was found to exert cytotoxity on hepatocellular carcinoma (HCC) cells regardless of p53 status. We found that (-)-Curine induced G1 arrest and cell death in HepG2 cells with wild-type p53 as well as Huh-7 cells with mutant p53. In HepG2 cells, knocking down of p53 did not change its cellular responses to (-)-Curine, and same degree of G1 arrest and cell death were occurred after p53 knockdown. |
| Molecular Weight | 594.7 |
| Formula | C36H38N2O6 |
| Cas No. | 436-05-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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