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(S,R,S)-AHPC-C4-NH2 hydrochloride
🥰Excellent
Catalog No. T18640Cas No. 2245697-83-8
Alias VHL Ligand-Linker Conjugates 13, VH032-C4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 28
(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate comprising the (S,R,S)-AHPC-based VHL ligand and a linker.
(S,R,S)-AHPC-C4-NH2 hydrochloride
🥰Excellent
Purity: 95.05%
Catalog No. T18640Alias VHL Ligand-Linker Conjugates 13, VH032-C4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 28Cas No. 2245697-83-8
(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate comprising the (S,R,S)-AHPC-based VHL ligand and a linker.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $32 | In Stock | |
| 10 mg | $39 | In Stock | |
| 25 mg | $64 | In Stock |
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View MoreInhibitors Related to "(S,R,S)-AHPC-C4-NH2 hydrochloride"
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Lenalidomide (CC-5013) is an immunomodulator with oral activity. Lenalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN), which selectively ubiquitinates and degrades two lymphoid transcription factors, IKZF1 and IKZF3, via the CRBN-CRL4 ubiquitin ligase, and is commonly used in the synthesis of PROTAC products.
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Thalidomide Cited
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CitedPomalidomide Cited
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Pomalidomide (CC-4047) is an anti-angiogenic and immunomodulatory agent. Pomalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN) and is commonly used in the synthesis of PROTAC products.
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Cited(S,R,S)-AHPC hydrochloride
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(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
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(S,R,S)-AHPC
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5-Aminothalidomide is a E3 ligase ligand used in PROTAC technology.
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Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) is a thalidomide-based Cereblon ligand that binds to the IRAK4 protein ligand via a linker to form PROTACIRAK4 degrader-1.
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Thalidomide-5-OH
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Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTAC.
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Thalidomide-O-COOH
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Purity:95.05%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | (S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate comprising the (S,R,S)-AHPC-based VHL ligand and a linker. |
| In vitro | PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein[1]. |
| Alias | VHL Ligand-Linker Conjugates 13, VH032-C4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 28 |
| Molecular Weight | 566.16 |
| Formula | C27H40ClN5O4S |
| Cas No. | 2245697-83-8 |
| Smiles | CC(C)(C)[C@@H](C(N(C[C@@H](C1)O)[C@@H]1C(NCc(cc1)ccc1-c1c(C)ncs1)=O)=O)NC(CCCCN)=O.Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 50 mg/mL (88.31 mM) DMSO: 109.6 mg/mL (193.58 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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