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CRBN modulator-1
🥰Excellent
Catalog No. T8824Cas No. 2407829-65-4
Alias WUN29654
CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.
CRBN modulator-1
🥰Excellent
Purity: 99.36%
Catalog No. T8824Alias WUN29654Cas No. 2407829-65-4
CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $33 | In Stock | |
| 5 mg | $73 | In Stock | |
| 10 mg | $118 | In Stock | |
| 25 mg | $223 | In Stock | |
| 50 mg | $333 | In Stock | |
| 100 mg | $469 | In Stock | |
| 500 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $79 | In Stock |
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View MoreInhibitors Related to "CRBN modulator-1"
Lenalidomide
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CC-5013
T1642191732-72-6
Lenalidomide (CC-5013) is an immunomodulator with oral activity. Lenalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN), which selectively ubiquitinates and degrades two lymphoid transcription factors, IKZF1 and IKZF3, via the CRBN-CRL4 ubiquitin ligase, and is commonly used in the synthesis of PROTAC products.
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CitedThalidomide-5-OH
2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
T929164567-60-8
Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTAC.
- $29
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5-Aminothalidomide
T40017191732-76-0
5-Aminothalidomide is a E3 ligase ligand used in PROTAC technology.
- $34
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Thalidomide 4-fluoride
E3 ligase Ligand 4
T7755835616-60-9
Thalidomide 4-fluoride (E3 ligase Ligand 4) (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
- $29
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(S,R,S)-AHPC
VHL ligand 1, VH032-NH2, MDK7526
T84121448297-52-6
(S,R,S)-AHPC (VH032-NH2) is a VH032-based ligand for recruiting the von Hippel-Lindau (VHL) protein, potentially useful for the targeted degradation of the androgen receptor.
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Pomalidomide Cited
CC-4047
T238419171-19-8
Pomalidomide (CC-4047) is an anti-angiogenic and immunomodulatory agent. Pomalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN) and is commonly used in the synthesis of PROTAC products.
- $52
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CitedThalidomide 5-fluoride
H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-
T9381835616-61-0
Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) is a thalidomide-based Cereblon ligand that binds to the IRAK4 protein ligand via a linker to form PROTACIRAK4 degrader-1.
- $29
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Thalidomide Cited
Thalomid, Sedoval
T021350-35-1
Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
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CitedThalidomide-O-COOH
TCE35031, E3 ligase Ligand 3, Cereblon ligand 3
T77531061605-21-7
Thalidomide-O-COOH (Cereblon ligand 3) is a Thalidomide-based Cereblon ligand utilized for recruiting the CRBN protein and can be linked to a protein ligand via a linker to create PROTACs.
- $29
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Lenalidomide-Br
T180642093387-36-9
Lenalidomide-Br (Compound 41), a derivative of Lenalidomide, acts as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound can be conjugated to a protein ligand via a linker to create PROTACs, such as the PROTAC STAT3 degrader SD-36.
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Thalidomide-4-OH
E3 ligase Ligand 2, Cereblon ligand 2
T77635054-59-1
Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs
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(S,R,S)-AHPC hydrochloride
VHL Ligand 1 hydrochloride, ULM-1, Protein degrader 1 hydrochloride
T42071448189-80-7
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
- $48
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Purity:99.36%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM. |
| Alias | WUN29654 |
| Molecular Weight | 324.29 |
| Formula | C17H12N2O5 |
| Cas No. | 2407829-65-4 |
| Smiles | Oc1cc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c3cccc(c1)c23 |
| Relative Density. | 1.587 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mM, Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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