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Thalidomide-O-amido-C6-NH2 TFA
🥰Excellent
Catalog No. T17919Cas No. 1950635-14-9
Alias E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate, E3 Ligase Ligand-Linker Conjugates 25 TFA, Cereblon Ligand-Linker Conjugates 11 TFA
Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) is a synthesized E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker.
Thalidomide-O-amido-C6-NH2 TFA
🥰Excellent
Purity: 95.16%
Catalog No. T17919Alias E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate, E3 Ligase Ligand-Linker Conjugates 25 TFA, Cereblon Ligand-Linker Conjugates 11 TFACas No. 1950635-14-9
Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) is a synthesized E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock | |
| 5 mg | $46 | In Stock | |
| 10 mg | $68 | In Stock | |
| 25 mg | $113 | In Stock | |
| 50 mg | $167 | In Stock | |
| 100 mg | $262 | In Stock | |
| 200 mg | $386 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $80 | In Stock |
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Purity:95.16%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) is a synthesized E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker. |
| In vitro | PROTACs consist of two ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
| Alias | E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate, E3 Ligase Ligand-Linker Conjugates 25 TFA, Cereblon Ligand-Linker Conjugates 11 TFA |
| Molecular Weight | 1087.95 |
| Formula | C46H53F6N8O16 |
| Cas No. | 1950635-14-9 |
| Smiles | O=C(NCCCCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(O)C(F)(F)FC1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCCCCCN.C(=O)(C(F)(F)F)O |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 105.5 mg/mL (193.76 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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