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Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11) is a Thalidomide-based synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand and a linker, used in the production of PROTACs (proteolysis-targeting chimeras).
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Description | Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11) is a Thalidomide-based synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand and a linker, used in the production of PROTACs (proteolysis-targeting chimeras). |
In vitro | PROTACs are molecules consisting of two ligands connected by a linker: one ligand targets an E3 ubiquitin ligase and the other targets the protein of interest, thereby leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
Alias | Thalidomide-O-amido-C6-NH2, E3LigaseLigand-LinkerConjugates25, Cereblon Ligand-Linker Conjugates 11 |
Molecular Weight | 430.45 |
Formula | C21H26N4O6 |
Cas No. | 1950635-13-8 |
Relative Density. | 1.341 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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