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Thalidomide-O-amido-C6-NH2

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Catalog No. T39361Cas No. 1950635-13-8
Alias Thalidomide-O-amido-C6-NH2, E3LigaseLigand-LinkerConjugates25, Cereblon Ligand-Linker Conjugates 11

Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11) is a Thalidomide-based synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand and a linker, used in the production of PROTACs (proteolysis-targeting chimeras).

Thalidomide-O-amido-C6-NH2

Thalidomide-O-amido-C6-NH2

😃Good
Catalog No. T39361Alias Thalidomide-O-amido-C6-NH2, E3LigaseLigand-LinkerConjugates25, Cereblon Ligand-Linker Conjugates 11Cas No. 1950635-13-8
Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11) is a Thalidomide-based synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand and a linker, used in the production of PROTACs (proteolysis-targeting chimeras).
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Product Introduction

Bioactivity
Description
Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11) is a Thalidomide-based synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand and a linker, used in the production of PROTACs (proteolysis-targeting chimeras).
In vitro
PROTACs are molecules consisting of two ligands connected by a linker: one ligand targets an E3 ubiquitin ligase and the other targets the protein of interest, thereby leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
AliasThalidomide-O-amido-C6-NH2, E3LigaseLigand-LinkerConjugates25, Cereblon Ligand-Linker Conjugates 11
Chemical Properties
Molecular Weight430.45
FormulaC21H26N4O6
Cas No.1950635-13-8
Relative Density.1.341 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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