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N-Butanoyl-L-homoserine lactone

N-Butanoyl-L-homoserine lactone
N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It exhibits antibacterial activity and is employed in antibacterial biofilm[1].
Catalog No. T18408Cas No. 67605-85-0
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Purity:99.43%
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N-Butanoyl-L-homoserine lactone

Catalog No. T18408Alias N-Butyryl-L-homoserine lactone, C4-HSLCas No. 67605-85-0

N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It exhibits antibacterial activity and is employed in antibacterial biofilm[1].
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Product Introduction

Bioactivity
Description
N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It exhibits antibacterial activity and is employed in antibacterial biofilm[1].
In vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
AliasN-Butyryl-L-homoserine lactone, C4-HSL
Chemical Properties
Molecular Weight171.19
FormulaC8H13NO3
Cas No.67605-85-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (175.24 mM), Sonication is recommended.
H2O: 30 mg/mL (175.24 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM5.8415 mL29.2073 mL58.4146 mL292.0731 mL
5 mM1.1683 mL5.8415 mL11.6829 mL58.4146 mL
10 mM0.5841 mL2.9207 mL5.8415 mL29.2073 mL
20 mM0.2921 mL1.4604 mL2.9207 mL14.6037 mL
50 mM0.1168 mL0.5841 mL1.1683 mL5.8415 mL
100 mM0.0584 mL0.2921 mL0.5841 mL2.9207 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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