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DBCO-PEG3 acetic-EVCit-PAB
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Catalog No. T87762Cas No. 2253947-17-8
DBCO-PEG3 acetic-EVCit-PAB, a cleavable 3-unit PEG ADC linker, plays a crucial role in the synthesis of antibody-drug conjugates (ADCs) [1]. This compound features a DBCO group, enabling it to engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, and is also utilized as a click chemistry reagent.
DBCO-PEG3 acetic-EVCit-PAB
😃Good
Catalog No. T87762Cas No. 2253947-17-8
DBCO-PEG3 acetic-EVCit-PAB, a cleavable 3-unit PEG ADC linker, plays a crucial role in the synthesis of antibody-drug conjugates (ADCs) [1]. This compound features a DBCO group, enabling it to engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, and is also utilized as a click chemistry reagent.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry |
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Product Introduction
Bioactivity
Chemical Properties
| Description | DBCO-PEG3 acetic-EVCit-PAB, a cleavable 3-unit PEG ADC linker, plays a crucial role in the synthesis of antibody-drug conjugates (ADCs) [1]. This compound features a DBCO group, enabling it to engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, and is also utilized as a click chemistry reagent. |
| Molecular Weight | 1041.2 |
| Formula | C54H72N8O13 |
| Cas No. | 2253947-17-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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