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Sofituzumab vedotin
😃Good
Catalog No. T81133Cas No. 1418200-58-4
Alias DMUC5754A
Sofituzumab vedotin (DMUC5754A) is an antibody-drug conjugate (ADC) comprising an anti-MUC16 antibody linked to monomethyl auristatin E (MMAE) via a protease-cleavable linker, utilized for cancer research [1].
Sofituzumab vedotin
Sofituzumab vedotin
😃Good
Catalog No. T81133Alias DMUC5754ACas No. 1418200-58-4
Sofituzumab vedotin (DMUC5754A) is an antibody-drug conjugate (ADC) comprising an anti-MUC16 antibody linked to monomethyl auristatin E (MMAE) via a protease-cleavable linker, utilized for cancer research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | Inquiry | Backorder | |
| 5 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Sofituzumab vedotin (DMUC5754A) is an antibody-drug conjugate (ADC) comprising an anti-MUC16 antibody linked to monomethyl auristatin E (MMAE) via a protease-cleavable linker, utilized for cancer research [1]. |
| In vitro | Sofituzumab vedotin (DMUC5754A) is an antibody-drug conjugate (ADC) composed of a humanized IgG1 anti-MUC16 monoclonal antibody linked to the potent mitotic inhibitor MMAE via a protease-labile linker, maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl [2]. |
| In vivo | Sofituzumab vedotin (3A5-VC-MMAE; 2 and 2.8 mg/kg; IV; once weekly for 3 or 4 total doses) demonstrated robust antitumor activity in a human MUC16-expressing OVCAR-3 mouse xenograft model [3]. |
| Alias | DMUC5754A |
| Cas No. | 1418200-58-4 |
Storage & Solubility Information
| Storage | store at -20°C | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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