store at low temperature,keep away from direct sunlight
store at -20°C
Disitamab vedotin (RC-48) is an antibo-active molecular conjugate (ADC) containing a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) that binds to the cytotoxic agent MMAE via a degradable linker. Disitamab vedotin showed anti-tumor and anti-proliferation activities in gastric cancer cells with different HER-2 expression levels, and inhibited the expression of HER-2 protein in gastric cancer cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 347.00 | |
5 mg | In stock | $ 838.00 | |
10 mg | In stock | $ 1,160.00 | |
25 mg | In stock | $ 1,720.00 | |
50 mg | In stock | $ 2,320.00 |
Description | Disitamab vedotin (RC-48) is an antibo-active molecular conjugate (ADC) containing a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) that binds to the cytotoxic agent MMAE via a degradable linker. Disitamab vedotin showed anti-tumor and anti-proliferation activities in gastric cancer cells with different HER-2 expression levels, and inhibited the expression of HER-2 protein in gastric cancer cells. |
In vitro | The antibody component was a humanized monoclonal antibody designed to target HER2, while the small molecule toxin utilized was monomethyl auristatin E (MMAE), a synthetic antineoplastic agent. A protease-cleavable linker was used to covalently attach MMAE to the antibody.[2] |
Synonyms | RC 48, RC-48, RC48 |
Molecular Weight | N/A |
CAS No. | 2136633-23-1 |
store at low temperature,keep away from direct sunlight
store at -20°C
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Disitamab vedotin 2136633-23-1 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR RC 48 RC-48 RC48 inhibitor inhibit