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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $347 | In Stock | |
5 mg | $838 | In Stock | |
10 mg | $1,160 | In Stock | |
25 mg | $1,720 | In Stock | |
50 mg | $2,320 | In Stock |
Description | Disitamab vedotin (RC-48) is an antibo-active molecular conjugate (ADC) containing a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) that binds to the cytotoxic agent MMAE via a degradable linker. Disitamab vedotin showed anti-tumor and anti-proliferation activities in gastric cancer cells with different HER-2 expression levels, and inhibited the expression of HER-2 protein in gastric cancer cells. |
In vitro | The antibody component was a humanized monoclonal antibody designed to target HER2, while the small molecule toxin utilized was monomethyl auristatin E (MMAE), a synthetic antineoplastic agent. A protease-cleavable linker was used to covalently attach MMAE to the antibody.[2] |
Alias | RC 48, RC-48, RC48 |
Molecular Weight | Approximately 144.15 kDa |
Cas No. | 2136633-23-1 |
Storage | keep away from direct sunlight | store at -20°C | Shipping with blue ice. |
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