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Brentuximab vedotin
🥰Excellent
Catalog No. T76707Cas No. 914088-09-8
Alias SGN-35
Brentuximab vedotin (SGN-35) is a CD30-targeting antibody-active molecule conjugate (ADC) that combines a CD30 monoclonal antibody with the microtubule disrupting agent monomethylauristatin E for the study of lymphoma.
Brentuximab vedotin
Brentuximab vedotin
🥰Excellent
Purity: 97.73% (SEC-HPLC)
Catalog No. T76707Alias SGN-35Cas No. 914088-09-8
Brentuximab vedotin (SGN-35) is a CD30-targeting antibody-active molecule conjugate (ADC) that combines a CD30 monoclonal antibody with the microtubule disrupting agent monomethylauristatin E for the study of lymphoma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $413 | In Stock | |
| 5 mg | $979 | In Stock | |
| 25 mg | $1,960 | In Stock |
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Disitamab vedotin
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Concentration:5.35 mg/mL
Purity:97.73% (SEC-HPLC)
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Brentuximab vedotin (SGN-35) is a CD30-targeting antibody-active molecule conjugate (ADC) that combines a CD30 monoclonal antibody with the microtubule disrupting agent monomethylauristatin E for the study of lymphoma. |
| In vitro | METHODS: Three cancer cell lines derived from hematological malignancies (HH, DND-41, and MOLT-4 cells) were treated with Brentuximab vedotin (0.0068, 0.020, 0.068, 0.20, 0.68, 2.0, 6.8, 20, 68 nM, 72 hours) and cell viability was measured using the CellTiter-Glo luminescence assay. RESULTS: Brentuximab vedotin reduced the viability of HH cells in a dose-dependent manner with an IC50 value of 0.058 nM, but did not reduce the viability of DND-41 and MOLT-4 cells. [3] |
| In vivo | METHODS: Brentuximab vedotin (0.1 mg/kg, once a week, intravenously), chidamide (15 mg/kg, once a day, orally), or BV combined with chidamide were used to treat severe combined immunodeficient mice bearing tumor xenografts of HH cells mixed with BD Matrigel to study tumor growth in vivo. RESULTS: The combination of brentuximab vedotin and chidamide effectively inhibited tumor growth. [3] |
| Alias | SGN-35 |
| Molecular Weight | 145.58 kDa |
| Cas No. | 914088-09-8 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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