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Patritumab deruxtecan
😃Good
Catalog No. T77910Cas No. 2227102-46-5
Alias U3-1287, HER3-DXd
Patritumab deruxtecan (HER3-DXd), an antibody-drug conjugate (ADC), comprises a fully human anti-HER3 IgG1 monoclonal antibody, Patritumab, linked to a topoisomerase I inhibitor payload through a tetrapeptide-based cleavable linker, demonstrating anticancer activity [1].
Patritumab deruxtecan
Patritumab deruxtecan
😃Good
Catalog No. T77910Alias U3-1287, HER3-DXdCas No. 2227102-46-5
Patritumab deruxtecan (HER3-DXd), an antibody-drug conjugate (ADC), comprises a fully human anti-HER3 IgG1 monoclonal antibody, Patritumab, linked to a topoisomerase I inhibitor payload through a tetrapeptide-based cleavable linker, demonstrating anticancer activity [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $797 | 6-8 weeks | |
| 5 mg | $2,320 | 6-8 weeks | |
| 10 mg | $3,480 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Patritumab deruxtecan (HER3-DXd), an antibody-drug conjugate (ADC), comprises a fully human anti-HER3 IgG1 monoclonal antibody, Patritumab, linked to a topoisomerase I inhibitor payload through a tetrapeptide-based cleavable linker, demonstrating anticancer activity [1]. |
| In vitro | Patritumab deruxtecan exhibits activity against breast cancer cells expressing HER3 mutations, regardless of HER2 overexpression [1]. It binds to the surface of all HER3 mutants and HER3 WT MDA-MB-231 cells in a concentration-dependent manner (0-100 nM), but does not bind to HER3^EV cells [1]. |
| Alias | U3-1287, HER3-DXd |
| Cas No. | 2227102-46-5 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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