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Glembatumumab

Catalog No. T77439Cas No. 1020264-78-1

Glembatumumab is a fully human IgG2 monoclonal antibody targeting the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. It is a naked antibody to Glembatumumab vedotin and can be used to study antibody-activated molecule couplings (Glembatumumab vedotin).

Glembatumumab

Glembatumumab

Purity: 97.31% (SEC-HPLC)
Catalog No. T77439Cas No. 1020264-78-1
Glembatumumab is a fully human IgG2 monoclonal antibody targeting the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. It is a naked antibody to Glembatumumab vedotin and can be used to study antibody-activated molecule couplings (Glembatumumab vedotin).
Pack SizePriceAvailabilityQuantity
1 mg$263In Stock
5 mg$588In Stock
10 mg$947In Stock
25 mg$1,380In Stock
50 mg$1,890In Stock
100 mg$2,550In Stock
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Concentration:8.53 mg/mL
Purity:97.31% (SEC-HPLC)
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Product Introduction

Bioactivity
Description
Glembatumumab is a fully human IgG2 monoclonal antibody targeting the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. It is a naked antibody to Glembatumumab vedotin and can be used to study antibody-activated molecule couplings (Glembatumumab vedotin).
In vitro
Glembatumumab vedotin (CR011-vcMMAE) exhibits minimal growth inhibition at a concentration of 0.16 μg/mL in UACC62 melanoma cells without prior MEK inhibitor pretreatment for 72 hours. In contrast, the same dose of CR011-vcMMAE shows stronger growth inhibition in UACC62 cells pre-treated with a MEK inhibitor[1].
In vivo
Glembatumumab vedotin, administered via intravenous injection at a dose of 2.5 mg/kg three times within 7 days, inhibits tumor growth and demonstrates good tolerance in CB17SC scid?/? female xenograft mice[2].
Chemical Properties
Molecular Weight145.56 kDa
Cas No.1020264-78-1
Storage & Solubility Information
Storagestore at low temperature | store at -80°C | Shipping with blue ice.

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