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Trastuzumab deruxtecan

Trastuzumab deruxtecan
Trastuzumab deruxtecan (T-DXd) is an antibody-activated molecule coupling (ADC) with anticancer and antitumour activity.Trastuzumab deruxtecan has been shown to have an ameliorative effect in HER2-positive breast and gastric cancers.
Catalog No. T36646Cas No. 1826843-81-5
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Concentration:9.37 mg/mL
Purity:95%
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Trastuzumab deruxtecan

Catalog No. T36646Cas No. 1826843-81-5
Trastuzumab deruxtecan (T-DXd) is an antibody-activated molecule coupling (ADC) with anticancer and antitumour activity.Trastuzumab deruxtecan has been shown to have an ameliorative effect in HER2-positive breast and gastric cancers.
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Pack SizePriceAvailabilityQuantity
1 mg$728In Stock
5 mg$1,480In Stock
10 mg$1,960In Stock
25 mg$2,980In Stock
50 mg$3,930In Stock
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Product Introduction

Bioactivity
Description
Trastuzumab deruxtecan (T-DXd) is an antibody-activated molecule coupling (ADC) with anticancer and antitumour activity.Trastuzumab deruxtecan has been shown to have an ameliorative effect in HER2-positive breast and gastric cancers.
Targets&IC50
Axl(KPL-4 cells):109.7 pM
In vitro
Trastuzumab deruxtecan, at concentrations ranging from 1 pM to 10 nM for 5 days (solution), inhibits the growth of HER2-positive KPL-4 cells, with an IC50 of 109.7 pM[4].Trastuzumab deruxtecan, at 10 nM for 5 days (solution), shows bystander killing effects in HER2-negative MDA-MB-468 cells[4].
In vivo
Trastuzumab deruxtecan (solution) at a single intravenous dose of 3 mg/kg exhibits antitumor activity against not only HER2-positive tumors but also HER2-negative tumors under the co-inoculated condition[4].Trastuzumab deruxtecan (solution) administered intravenously on days 0 and 7 at a dose of 10 mg/kg inhibits tumor growth in the EMT6-hHER2 syngeneic mouse model[3].Female BALB/c nude mice injected with NCI‐N87 and MDA‐MB‐468‐Luc cells[4]
AliasDS-8201a, VRN-101099, DS 8201, T-DXd
Chemical Properties
Molecular WeightApproximately 45.42 kDa
Cas No.1826843-81-5
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice.

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