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Trastuzumab deruxtecan
🥰Excellent
Catalog No. T36646Cas No. 1826843-81-5
Alias VRN-101099, T-DXd, DS-8201a, DS 8201
Trastuzumab deruxtecan (T-DXd) is an antibody-active molecule conjugate (ADC) with anticancer and antitumor activity, which is composed of a monoclonal antibody targeting human epidermal growth factor receptor 2 (HER2) coupled to a topoisomerase I inhibitor (DXd). Trastuzumab deruxtecan has an improved effect on the treatment of HER2-positive breast cancer and gastric cancer.
Trastuzumab deruxtecan
🥰Excellent
Purity: 98.49% (SEC-HPLC)
Catalog No. T36646Alias VRN-101099, T-DXd, DS-8201a, DS 8201Cas No. 1826843-81-5
Trastuzumab deruxtecan (T-DXd) is an antibody-active molecule conjugate (ADC) with anticancer and antitumor activity, which is composed of a monoclonal antibody targeting human epidermal growth factor receptor 2 (HER2) coupled to a topoisomerase I inhibitor (DXd). Trastuzumab deruxtecan has an improved effect on the treatment of HER2-positive breast cancer and gastric cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $728 | In Stock | |
| 5 mg | $1,480 | In Stock | |
| 10 mg | $1,960 | In Stock | |
| 25 mg | $2,980 | In Stock | |
| 50 mg | $3,930 | In Stock |
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Concentration:9.37 mg/mL
Purity:98.49% (SEC-HPLC)
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Trastuzumab deruxtecan (T-DXd) is an antibody-active molecule conjugate (ADC) with anticancer and antitumor activity, which is composed of a monoclonal antibody targeting human epidermal growth factor receptor 2 (HER2) coupled to a topoisomerase I inhibitor (DXd). Trastuzumab deruxtecan has an improved effect on the treatment of HER2-positive breast cancer and gastric cancer. |
| Targets&IC50 | Axl(KPL-4 cells):109.7 pM |
| In vitro | METHODS: HER2-positive KPL-4 cells were treated with Trastuzumab deruxtecan (T-DXd) (1 pM-10 nM, 5 days) and cell viability was calculated. RESULTS: Trastuzumab deruxtecan can inhibit the growth of HER2-positive KPL-4 cells with an IC50 value of 109.7 pM. [2] METHODS: Trastuzumab deruxtecan (10 nM, 5 days) was used to treat co-cultured HER2-positive KPL-4 cells and HER2-negative MDA-MB-468 cells, and the number of viable cells was measured to determine whether it induced bystander killing. RESULTS: Trastuzumab deruxtecan killed both KPL-4 and MDA-MB-468 cells. [2] |
| In vivo | METHODS: Trastuzumab deruxtecan (T-DXd) (10 mg/kg, intravenous injection) was used to treat EMT6-hHER2 tumor-bearing mice, and the changes in tumors in the mice were observed. RESULTS: Trastuzumab deruxtecan significantly inhibited tumor growth in EMT6-hHER2 tumor-bearing mice 18 days after treatment. [1] |
| Alias | VRN-101099, T-DXd, DS-8201a, DS 8201 |
| Molecular Weight | 145 kDa (average) |
| Cas No. | 1826843-81-5 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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