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Trastuzumab emtansine
😃Good
Catalog No. T36647Cas No. 1018448-65-1
Alias T-DM1
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory derivative of maytansine, and is utilized in the investigation of advanced breast cancer[1][2].
Trastuzumab emtansine
😃Good
Catalog No. T36647Alias T-DM1Cas No. 1018448-65-1
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory derivative of maytansine, and is utilized in the investigation of advanced breast cancer[1][2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,320 | Backorder | |
| 10 mg | $2,150 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory derivative of maytansine, and is utilized in the investigation of advanced breast cancer[1][2]. |
| In vitro | Trastuzumab emtansine (2 μg/mL; 3 d) markedly inhibits the proliferation of epithelial ovarian cancer (EOC) cells[2]. |
| In vivo | Trastuzumab emtansine (15 mg/kg; i.v., three to five times weekly for 3 weeks) demonstrates significant anti-tumor effects in CB-17/SCID mice (6 weeks) injected with OVA10 cells[2]. |
| Alias | T-DM1 |
| Formula | N/A |
| Cas No. | 1018448-65-1 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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