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Belantamab mafodotin
😃Good
Catalog No. T77903Cas No. 2050232-20-5
Alias GSK2857916, Belantamab mafodotin-blm
Belantamab mafodotin (GSK2857916) is a conjugate of a humanized, targeted monoclonal antibody directed against the B cell maturation antigen (BCMA) and the cytotoxic agent McMMAF, exhibiting anti-myeloma activity [1] [2].
Belantamab mafodotin
Belantamab mafodotin
😃Good
Catalog No. T77903Alias GSK2857916, Belantamab mafodotin-blmCas No. 2050232-20-5
Belantamab mafodotin (GSK2857916) is a conjugate of a humanized, targeted monoclonal antibody directed against the B cell maturation antigen (BCMA) and the cytotoxic agent McMMAF, exhibiting anti-myeloma activity [1] [2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | Inquiry | Backorder | |
| 5 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Belantamab mafodotin (GSK2857916) is a conjugate of a humanized, targeted monoclonal antibody directed against the B cell maturation antigen (BCMA) and the cytotoxic agent McMMAF, exhibiting anti-myeloma activity [1] [2]. |
| In vitro | Belantamab mafodotin exhibits a high affinity for the human BCMA protein, as indicated by a dissociation constant (K d) of 1 nM [2]. Additionally, it triggers a G2/M phase arrest in multiple myeloma cells, with the extent of the effect dependent on both concentration and exposure duration [2]. Furthermore, belantamab mafodotin significantly enhances the phagocytosis of multiple myeloma cells by macrophages derived from macrophage colony-stimulating factor (M-CSF) stimulated monocytes [2]. |
| In vivo | Belantamab mafodotin significantly enhances survival relative to the vehicle in mice with OPM2 tumors [2]. |
| Alias | GSK2857916, Belantamab mafodotin-blm |
| Cas No. | 2050232-20-5 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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