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Val-Ala-PAB-MMAE

Name: Val-Ala-PAB-MMAE
Brand: TargetMol
SKU: T77883
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T77883Cas No. 1912408-92-4

Val-Ala-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), composed of the Val-Ala-PAB cleavable linker and MMAE, a potent microtubule inhibitor. It is designed to be cleaved by Cathepsin B within cancer cells, releasing MMAE to inhibit tubulin polymerization and induce apoptosis. This mechanism reduces toxicity to normal tissues while enhancing antitumor activity.

Val-Ala-PAB-MMAE

🥰Excellent

Purity: 99.02%

Catalog No. T77883Cas No. 1912408-92-4

Pack Size	Price	Availability
1 mg	$63	In Stock
5 mg	$139	In Stock
10 mg	$226	In Stock
25 mg	$410	In Stock
50 mg	$654	In Stock

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Purity:99.02%

Resource Download

COA HPLC MS

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	1037.33
Formula	C₅₅H₈₈N₈O₁₁
Cas No.	1912408-92-4
Smiles	[C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OCC3=CC=C(NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)C=C3)=O)C)C(C)C)=O)[C@@H](C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (77.12 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9640 mL	4.8201 mL	9.6401 mL	48.2007 mL
5 mM	0.1928 mL	0.9640 mL	1.9280 mL	9.6401 mL
10 mM	0.0964 mL	0.4820 mL	0.9640 mL	4.8201 mL
20 mM	0.0482 mL	0.2410 mL	0.4820 mL	2.4100 mL
50 mM	0.0193 mL	0.0964 mL	0.1928 mL	0.9640 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc