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Val-Ala-PAB-MMAE
Catalog No. T77883Cas No. 1912408-92-4
Val-Ala-PAB-MMAE is a drug-linker conjugate used in antibody-drug conjugates (ADCs), consisting of the ADC linker Val-Ala-PAB and the cytotoxic agent monomethyl auristatin E (MMAE), which acts as a potent tubulin inhibitor.
Val-Ala-PAB-MMAE
Catalog No. T77883Cas No. 1912408-92-4
Val-Ala-PAB-MMAE is a drug-linker conjugate used in antibody-drug conjugates (ADCs), consisting of the ADC linker Val-Ala-PAB and the cytotoxic agent monomethyl auristatin E (MMAE), which acts as a potent tubulin inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE . MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization[1].
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Fmoc-Val-Cit-PAB-MMAE
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Fmoc-Val-Cit-PAB-MMAE is consisted of the ADCs linker (Fmoc-Val-Cit-PAB) and potent tubulin inhibitor (MMAE). Fmoc-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC.
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CL2A-SN-38
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Mc-MMAE
Cited
Maleimidocaproyl-monomethylauristatin E
T18312863971-24-8
Mc-MMAE (Maleimidocaproyl-monomethylauristatin E) is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.
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CitedMcMMAF
Maleimidocaproyl monomethylauristatin F
T16031863971-19-1
McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC linker), which is ready to conjugate to antibody or other proteins or biopolymers. Mafodotin is a useful agent for make antibody drug conjugate (ADC) for targeted drug delivery.
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Product Introduction
Bioactivity
Chemical Properties
| Description | Val-Ala-PAB-MMAE is a drug-linker conjugate used in antibody-drug conjugates (ADCs), consisting of the ADC linker Val-Ala-PAB and the cytotoxic agent monomethyl auristatin E (MMAE), which acts as a potent tubulin inhibitor. |
| Molecular Weight | 1037.33 |
| Formula | C55H88N8O11 |
| Cas No. | 1912408-92-4 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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