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Anti-CD22-NMS249
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Catalog No. T9901A-233
Anti-CD22-NMS249 is an antibody-drug conjugate (ADC) that targets CD22, comprising the humanized anti-CD22 antibody Pinatuzumab, a cleavable linker (Mc-VC-PAB), and the effective payload of DNA topoisomerase II inhibitor PNU-159682. This compound is utilized in the study of non-Hodgkin lymphoma (NHL).
Anti-CD22-NMS249
😃Good
Catalog No. T9901A-233
Anti-CD22-NMS249 is an antibody-drug conjugate (ADC) that targets CD22, comprising the humanized anti-CD22 antibody Pinatuzumab, a cleavable linker (Mc-VC-PAB), and the effective payload of DNA topoisomerase II inhibitor PNU-159682. This compound is utilized in the study of non-Hodgkin lymphoma (NHL).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | Inquiry | Backorder | |
| 5 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Anti-CD22-NMS249 is an antibody-drug conjugate (ADC) that targets CD22, comprising the humanized anti-CD22 antibody Pinatuzumab, a cleavable linker (Mc-VC-PAB), and the effective payload of DNA topoisomerase II inhibitor PNU-159682. This compound is utilized in the study of non-Hodgkin lymphoma (NHL). |
| In vitro | Anti-CD22-NMS249 effectively inhibits the proliferation of non-Hodgkin lymphoma (NHL) cell lines, displaying IC50 values of 0.058 μg/mL for BJAB.Luc, 0.030 μg/mL for Granta-519, 0.0221 μg/mL for SuDHL4.Luc, and 0.010 μg/mL for WSU-DLCL2. |
| In vivo | The chemical compound Anti-CD22-NMS249 administered as a single intravenous injection at dosages ranging from 0.5 to 2 mg/kg, induced tumor stasis in four different xenograft models. |
| Molecular Weight | 818.91 |
| Formula | C41H45F3N8O5S |
Storage & Solubility Information
| Storage | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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