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PPC-NHS ester
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Catalog No. T18559Cas No. 107348-47-0
Alias 2,5-Dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate
PPC-NHS ester, a cleavable linker crucial in ADC synthesis, facilitates the attachment of cytotoxic drugs to antibodies for precise delivery to cells or proteins. Its cleavable nature ensures controlled drug release, thereby optimizing the effectiveness of ADCs (Antibody-Drug Conjugates).
PPC-NHS ester
😃Good
Catalog No. T18559Alias 2,5-Dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoateCas No. 107348-47-0
PPC-NHS ester, a cleavable linker crucial in ADC synthesis, facilitates the attachment of cytotoxic drugs to antibodies for precise delivery to cells or proteins. Its cleavable nature ensures controlled drug release, thereby optimizing the effectiveness of ADCs (Antibody-Drug Conjugates).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $44 | 5 days |
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View MoreInhibitors Related to "PPC-NHS ester"
Succinic anhydride
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Fmoc-8-amino-3,6-dioxaoctanoic acid
Fmoc-NH-PEG2-CH2COOH
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Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.
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DSG Crosslinker
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DSG Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).
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Fmoc-Gly-Gly-OH
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Fmoc-Gly-Gly-OH, a cleavable ADC linker, can be used in the synthesis of antibody-drug conjugates (ADCs).
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DSS Crosslinker
T1517668528-80-3
DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is a homobifunctional crosslinker that is cell membrane permeable, with amine-reactive NHS esters at both ends of an 8-atom [11.4 angstrom] spacer arm for conjugating proteins, including intracellular proteins.
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SMCC
N-Succinimidyl 4-(N-maleimidomethyl)cycl
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SMCC (N-Succinimidyl 4-(N-maleimidomethyl)cycl) is a heterobifunctional protein crosslinker.
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Boc-NH-PEG4-CH2COOH
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Boc-NH-PEG4-CH2COOH is a cleavable ADC linker utilized in the development of antibody-drug conjugates (ADC)[1].
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DSP Crosslinker
Cited
T1517557757-57-0
DSP Crosslinker, used in antibody-drug conjugates (ADCs) synthesis, is a cleavable ADC linker[1].
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CitedVal-cit-PAB-OH
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Val-cit-PAB-OH is an ADC linker that is cleavable.
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FMoc-Val-Cit-PAB-PNP
T7767863971-53-3
Fmoc-Val-Cit-PAB-PNP is a linker used in Antibody-Drug Conjugation (ADC).
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N-Boc-PEG5-bromide
T162181392499-32-9
N-Boc-PEG5-bromide is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and serves as a PROTAC linker based on PEG and Alkyl/ether.
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Product Introduction
Bioactivity
Chemical Properties
| Description | PPC-NHS ester, a cleavable linker crucial in ADC synthesis, facilitates the attachment of cytotoxic drugs to antibodies for precise delivery to cells or proteins. Its cleavable nature ensures controlled drug release, thereby optimizing the effectiveness of ADCs (Antibody-Drug Conjugates). |
| In vitro | ADCs consist of an antibody conjugated to an ADC cytotoxin via an ADC linker[1]. |
| Alias | 2,5-Dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate |
| Molecular Weight | 326.39 |
| Formula | C13H14N2O4S2 |
| Cas No. | 107348-47-0 |
| Relative Density. | 1.43g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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