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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | Inquiry | Backorder | |
500 mg | Inquiry | Backorder |
Description | Azide-PEG3-Tos is a PEG-based PROTAC linker utilized in the synthesis of PROTACs[1]. It is a non-cleavable 3 unit PEG ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[2]. |
In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
Molecular Weight | 329.37 |
Formula | C13H19N3O5S |
Cas No. | 178685-33-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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