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Propargyl-PEG2-NHBoc is a cleavable ADC linker used for creating antibody-drug conjugates (ADCs). Additionally, this PEG-based PROTAC linker is promising for synthesizing PROTACs[1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | Inquiry | 7-10 days | |
500 mg | Inquiry | 7-10 days |
Description | Propargyl-PEG2-NHBoc is a cleavable ADC linker used for creating antibody-drug conjugates (ADCs). Additionally, this PEG-based PROTAC linker is promising for synthesizing PROTACs[1]. |
In vitro | ADCs, or antibody-drug conjugates, consist of an antibody that is linked to a cytotoxic drug molecule via a specialized linker. This allows the antibody to specifically target certain cells or proteins, while the attached cytotoxin can selectively destroy those targeted cells. PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E5 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation. |
Molecular Weight | 243.3 |
Formula | C12H21NO4 |
Cas No. | 869310-84-9 |
Relative Density. | 1.033 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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