alkyl/ether

Hydroxy-Amino-bis(PEG1-C2-Boc) is an alkyl/ether-based linker used for the synthesis of PROTACs[1].

Boc-NH-C12-NH2 is an alkyl/ether-based PROTAC linker that can be used in PROTAC synthesis.

Mal-PEG1-Boc is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-PFP ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

6-Maleimidocaproic acid sulfo-NHS serves as an alkyl/ether-based PROTAC linker, facilitating the synthesis of PROTACs.

SPDP-C6-NHS ester is an alkyl/ether-based linker utilized in the synthesis of PROTACs[1].

NH2-C6-NH-Boc is a PROTAC linker. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC.

Boc-NH-C4-acid is a PROTAC linker belonging to the Alkyl/ether class, which can be used for the synthesis of PROTAC1 and can degrade EED, EZH2, and SUZ12 in PRC2.

Azido-PEG8-NHS ester is an 8 unit PEG linker with cleavable properties, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1]. This compound also serves as a PEG- and Alkyl/ether-based PROTAC linker, enabling its utilization in the synthesis of PROTACs[2].

Azido-PEG1-CH2CO2H is a PROTAC linker that refers to an alkyl/ether combination. Azido-PEG1-CH2CO2H can be used to synthesize PROTAC BRD4 Degrader-1[1].

4-(N-Boc-amino)-1,6-heptanedioic acid is an alkyl/ether-based linker, suitable for PROTAC synthesis [1].

Hydroxy-PEG2-C2-PFP ester, a PEG/Alkyl/ether-based PROteolysis TArgeting Chimeric (PROTAC) linker, is suitable for the synthesis of PROTACs.

N-Boc-PEG5-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

C-NH-Boc-C-Bis-(C-PEG1-Boc) is a versatile alkyl/ether-based PROTAC linker for synthesizing PROTACs[1].

Br-C10-methyl ester, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in the synthesis of a series of PROTACs (MS432). This compound incorporates a dual-ligand system connected via a linker; notably, one ligand interacts with the VHL portion.

Acid-PEG3-mono-methyl ester, an alkyl/ether-based PROTAC linker, facilitates the synthesis of PROTACs[1].

Propargyl-PEG1-Boc is an alkyl/ether-based linker employed for the synthesis of PROTACs[1].

NH-bis(PEG2-C2-Boc) is an alkyl/ether-based linker, utilized for the synthesis of PROTACs[1].

NH2-C4-NH-Boc (compound 15) is a PROTAC linker belonging to the Alkyl/ether class. NH2-C4-NH-Boc can be used to synthesize a series of PROTAC molecules.

N3-PEG3-CH2CH2-Boc is a cleavable 3 unit polyethylene glycol (PEG) ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. This compound also functions as a PEG- and alkyl/ether-based PROteolysis TArgeting Chimera (PROTAC) linker, suitable for the construction of PROTAC molecules[2].

SMPH Crosslinker is an alkyl/ether-based PROTAC linker utilized for synthesizing PROTACs[1].

Biotin-C10-NHS Ester is an alkyl/ether-based linker compound utilized in the synthesis of PROTACs[1].

Boc-bipiperidine-ethynylbenzoic acid is an alkyl/ether-based PROTAC linker commonly employed for the synthesis of ARD-61.

Boc-C16-NHS ester, an alkyl/ether-based PROTAC linker, enables the synthesis of PROTACs[1].

Propargyl-PEG4-CH2CH2-Boc is a PEG- and Alkyl/ether-based non-cleavable ADC linker. Propargyl-PEG5-Boc can used to synthesize ADC inhibitors of Galectin-3[1].

Br-PEG4-CH2-Boc, a PEG- and Alkyl/ether-based PROTAC linker, serves as a valuable component for the synthesis of PROTACs[1].

N-Me-N-bis(PEG4-C2-Boc) is a PROTAC linker utilizing alkyl and ether functionalities, which is instrumental in PROTAC synthesis. [1]

endo-BCN-O-PNB is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tri(t-butoxycarbonylethoxymethyl) ethanol, an alkyl/ether-based PROTAC linker, is suitable for synthesizing PROTACs[1].

Boc-NH-PEG1-CH2CH2COOH is a cleavable ADC linker, possessing one unit of PEG, that can be utilized for the synthesis of antibody-drug conjugates (ADCs) and PROTACs. Additionally, it serves as a PEG- and Alkyl/ether-based PROTAC linker [1][2].

Benzyloxy carbonyl-PEG3-C2-Boc, an alkyl/ether-based PROTAC linker, is a synthetic compound employed for the synthesis of PROTACs[1].

Amino-PEG4-benzyl ester, a PEG- and Alkyl/ether-based PROTAC linker, serves as a valuable component for the synthesis of PROTACs[1].

Acid-PEG3-C2-Boc is a compound used as a linker in the synthesis of PROTACs to facilitate the degradation of EGFR and the inhibition of mTOR[1][2]. It is classified as a PEG- and alkyl/ether-based PROTAC linker.

Azide-PEG6-amido-C16-Boc is an alkyl/ether-based PROTAC linker utilized in PROTAC synthesis[1].

Methyltetrazine-Ph-NHS ester is an alkyl/ether-based linker utilized for the synthesis of PROTACs, an abbreviation for proteolysis-targeting chimeras[1].

NH-bis(C1-PEG1-Boc) is an alkyl/ether-based PROTAC linker utilized for PROTAC synthesis[1].

Br-Boc-C2-azido is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Boc-Pip-alkyne-Ph-COOH, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in synthesizing PROTACs including ARD-266. This compound demonstrates significant efficacy in promoting the degradation of androgen receptor (AR) protein across AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1, showcasing DC50 values ranging from 0.2-1 nM[1].

Boc-NH-PPG2 is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG3-Boc is a PROTAC linker derived from PEG and alkyl/ether, utilized in the synthesis of PROTACs[1].

Bromoacetamido-PEG4-C2-Boc is a polyethylene glycol (PEG)- and alkyl/ether-based linker commonly employed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Azido-PEG1-methyl ester is an alkyl/ether-based linker employed for the synthesis of PROTACs[1].

N-Fmoc-N'-(azido-PEG4)-L-Lysine is an alkyl/ether-based PROTAC linker commonly utilized for the synthesis of PROTACs[1].

9-Decyn-1-ol is an alkyl/ether-based PROTAC linker suitable for synthesizing PROTACs. It serves as a conjugation agent to combine GDC-0068 and Lenalidomide, resulting in the formation of INY-03-041. INY-03-041 is a potent and highly selective pan-Akt degrader that operates through the PROTAC mechanism. It effectively inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively[1].

1,7-Bis-Boc-1,4,7-triazaheptane is an alkyl/ether-based PROTAC linker utilized for the synthesis of PROTACs[1].

BnOH-NH-bis-(C2-S)-propane-O-isoprene ester (PROTAC Linker 29) is an alkyl ether-based linker primarily utilized in the synthesis of PROTACs.