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SPDP-C6-NHS ester

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Catalog No. T16915Cas No. 158913-22-5

SPDP-C6-NHS ester is an alkyl/ether-based linker used in the synthesis of PROTACs [1].

SPDP-C6-NHS ester

SPDP-C6-NHS ester

😃Good
Catalog No. T16915Cas No. 158913-22-5
SPDP-C6-NHS ester is an alkyl/ether-based linker used in the synthesis of PROTACs [1].
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2 mg$315 days
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Product Introduction

Bioactivity
Description
SPDP-C6-NHS ester is an alkyl/ether-based linker used in the synthesis of PROTACs [1].
In vitro
PROTACs consist of two distinct ligands linked together: one targets an E3 ubiquitin ligase and the other binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively degrade target proteins[1].
Chemical Properties
Molecular Weight425.52
FormulaC18H23N3O5S2
Cas No.158913-22-5
Relative Density.1.36g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

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