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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | Inquiry | 7-10 days | |
500 mg | Inquiry | 7-10 days |
Description | Acid-PEG3-C2-Boc, a PEG- and alkyl/ether-based PROTAC linker, is utilized in PROTAC synthesis to facilitate the degradation of EGFR and inhibit mTOR[1][2]. |
In vitro | PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E3 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation. |
Molecular Weight | 306.35 |
Formula | C14H26O7 |
Cas No. | 1807539-06-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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