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Azido-PEG1-CH2COO-Cl

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Catalog No. T17477Cas No. 79598-49-5

Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker commonly used in the synthesis of PROTAC BRD4 Degrader-1[1].

Azido-PEG1-CH2COO-Cl

Azido-PEG1-CH2COO-Cl

😃Good
Catalog No. T17477Cas No. 79598-49-5
Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker commonly used in the synthesis of PROTAC BRD4 Degrader-1[1].
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Product Introduction

Bioactivity
Description
Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker commonly used in the synthesis of PROTAC BRD4 Degrader-1[1].
In vitro
PROTAC BRD4 Degrader-1 is a potent degrader of BRD4, demonstrating high efficiency with an IC50 value of 41.8 nM targeted against BRD4 BD1. This compound effectively degrades the BRD4 protein and inhibits c-Myc expression[1].
Chemical Properties
Molecular Weight163.56
FormulaC4H6ClN3O2
Cas No.79598-49-5
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

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