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Boc-11-aminoundecanoic acid

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Catalog No. T17638Cas No. 10436-25-6

Boc-11-aminoundecanoic acid is an alkyl/ether-based PROTAC linker used in the synthesis of [MS432].

Boc-11-aminoundecanoic acid

Boc-11-aminoundecanoic acid

🥰Excellent
Purity: 99.64%
Catalog No. T17638Cas No. 10436-25-6
Boc-11-aminoundecanoic acid is an alkyl/ether-based PROTAC linker used in the synthesis of [MS432].
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500 mg$29In Stock
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Purity:99.64%
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Product Introduction

Bioactivity
Description
Boc-11-aminoundecanoic acid is an alkyl/ether-based PROTAC linker used in the synthesis of [MS432].
In vitro
MS432 represents a pioneering and highly selective VHL-recruiting PROTAC degrader, specifically designed based on PD0325901, targeting MEK1 and MEK2[1]. PROTACs are bifunctional molecules, comprising two ligands joined by a linker; one ligand interacts with an E3 ubiquitin ligase, while the other targets the protein of interest. By leveraging the cell's ubiquitin-proteasome system, PROTACs achieve selective degradation of their target proteins.
Chemical Properties
Molecular Weight301.42
FormulaC16H31NO4
Cas No.10436-25-6
SmilesO(C(NCCCCCCCCCCC(O)=O)=O)C(C)(C)C
Relative Density.1.006 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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