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EGNHS

Name: EGNHS
Brand: TargetMol
SKU: T15203
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15203Cas No. 70539-42-3

Alias EGS crosslinker

EGNHS (EGS crosslinker) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

EGNHS

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Purity: 99.83%

Catalog No. T15203Alias EGS crosslinkerCas No. 70539-42-3

EGNHS (EGS crosslinker) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Pack Size	Price	Availability	Quantity
50 mg	$41	In Stock
100 mg	$66	In Stock

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Purity:99.83%

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COA HPLC HNMR

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Product Introduction

Bioactivity

Description	EGNHS (EGS crosslinker) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
In vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Alias	EGS crosslinker

Chemical Properties

Molecular Weight	456.36
Formula	C₁₈H₂₀N₂O₁₂
Cas No.	70539-42-3
Smiles	O=C(CCC(OCCOC(CCC(ON1C(CCC1=O)=O)=O)=O)=O)ON2C(CCC2=O)=O
Relative Density.	1.52g/cm3

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 90.0 mg/mL (197.2 mM), Sonication is recommended.

H2O: 3.8 mg/mL (8.33 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1913 mL	10.9563 mL	21.9125 mL	109.5626 mL
5 mM	0.4383 mL	2.1913 mL	4.3825 mL	21.9125 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2191 mL	1.0956 mL	2.1913 mL	10.9563 mL
20 mM	0.1096 mL	0.5478 mL	1.0956 mL	5.4781 mL
50 mM	0.0438 mL	0.2191 mL	0.4383 mL	2.1913 mL
100 mM	0.0219 mL	0.1096 mL	0.2191 mL	1.0956 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc