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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $37 | 5 days | |
10 mg | $51 | 5 days |
Description | m-PEG11-acid is a non-cleavable 11-unit polyethylene glycol (PEG) linker utilized in the synthesis of antibody-drug conjugates (ADCs) [1]. It is similarly employed as a PEG-based linker for PROTAC synthesis [2]. |
In vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
Molecular Weight | 544.63 |
Formula | C24H48O13 |
Cas No. | 2280998-74-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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