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MC-Val-Ala-PAB-PNP

Catalog No. T18318Cas No. 1639939-40-4

MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

MC-Val-Ala-PAB-PNP

MC-Val-Ala-PAB-PNP

Purity: 96.71%
Catalog No. T18318Cas No. 1639939-40-4
MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Pack SizePriceAvailabilityQuantity
5 mg$59In Stock
10 mg$81In Stock
25 mg$125In Stock
50 mg$178In Stock
100 mg$262In Stock
1 mL x 10 mM (in DMSO)$87In Stock
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Purity:96.71%
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Product Introduction

Bioactivity
Description
MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
In vitro
ADCs consist of an antibody attached to an ADC cytotoxin through an ADC linker.
Chemical Properties
Molecular Weight651.66
FormulaC32H37N5O10
Cas No.1639939-40-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (76.73 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5345 mL7.6727 mL15.3454 mL76.7271 mL
5 mM0.3069 mL1.5345 mL3.0691 mL15.3454 mL
10 mM0.1535 mL0.7673 mL1.5345 mL7.6727 mL
20 mM0.0767 mL0.3836 mL0.7673 mL3.8364 mL
50 mM0.0307 mL0.1535 mL0.3069 mL1.5345 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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