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MC-Val-Ala-PAB-PNP

MC-Val-Ala-PAB-PNP
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Purity:96.71%
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MC-Val-Ala-PAB-PNP

Catalog No. T18318Cas No. 1639939-40-4
MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$59In Stock
10 mg$81In Stock
25 mg$125In Stock
50 mg$178In Stock
100 mg$262In Stock
1 mL x 10 mM (in DMSO)$87In Stock
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Product Introduction

Bioactivity
Description
MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
In vitro
ADCs consist of an antibody attached to an ADC cytotoxin through an ADC linker.
Chemical Properties
Molecular Weight651.66
FormulaC32H37N5O10
Cas No.1639939-40-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (76.73 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5345 mL7.6727 mL15.3454 mL76.7271 mL
5 mM0.3069 mL1.5345 mL3.0691 mL15.3454 mL
10 mM0.1535 mL0.7673 mL1.5345 mL7.6727 mL
20 mM0.0767 mL0.3836 mL0.7673 mL3.8364 mL
50 mM0.0307 mL0.1535 mL0.3069 mL1.5345 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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