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THP-PEG6-OH is a polyethylene glycol (PEG)-based PROTAC linker, utilized in the synthesis of PROTACs[1]. It is also a non-cleavable three-unit PEG linker for antibody-drug conjugates (ADCs)[2].
Description | THP-PEG6-OH is a polyethylene glycol (PEG)-based PROTAC linker, utilized in the synthesis of PROTACs[1]. It is also a non-cleavable three-unit PEG linker for antibody-drug conjugates (ADCs)[2]. |
In vitro | PROTACs consist of two distinct ligands linked by a connector; one binds to an E3 ubiquitin ligase and the other to the target protein, utilizing the intracellular ubiquitin-proteasome system for selective degradation of target proteins[1]. ADCs are composed of an antibody attached to an ADC cytotoxin via an ADC linker[2]. |
Molecular Weight | 366.45 |
Formula | C17H34O8 |
Cas No. | 42607-87-4 |
Relative Density. | 1.10 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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