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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $49 | 5 days | |
5 mg | $79 | Backorder | |
10 mg | $115 | Backorder |
Description | Aminooxy-PEG2-azide is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1], as well as a non-cleavable 2-unit PEG ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[2]. |
In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
Molecular Weight | 190.2 |
Formula | C6H14N4O3 |
Cas No. | 1043426-13-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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