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Propargyl-PEG3-acid
Catalog No. T16605Cas No. 1347760-82-0
Propargyl-PEG3-acid is a non-cleavable (3-unit PEG) ADC linker. Propargyl-PEG3-acid is also a PEG-based PROTAC linker used to synthesize 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA and Propargyl-PEG3-acid[1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $29 | In Stock |
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View MoreInhibitors Related to "Propargyl-PEG3-acid"
Boc-NH-PEG3-CH2COOH
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m-PEG7-4-nitrophenyl carbonate
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Alkynyl Palmitic Acid
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Azido-PEG9-azide is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
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DBCO-S-S-PEG3-biotin
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DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label. PEG Linkers can be used in the synthesis of PROTACs.
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Amino-PEG11-amine
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Amino-PEG11-amine, a polyethylene glycol (PEG)-based linker with 12 units, facilitates the conjugation of two mono diethylstilbestrol (DES)-based ligands. This strategy enhances the preparation of selective and potent estrogen receptor (ER) antagonists, offering an innovative approach for endocrine therapy in breast cancer treatment.
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Br-C10-methyl ester
T176946287-90-7
Br-C10-methyl ester, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in the synthesis of a series of PROTACs (MS432). This compound incorporates a dual-ligand system connected via a linker; notably, one ligand interacts with the VHL portion.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Propargyl-PEG3-acid is a non-cleavable (3-unit PEG) ADC linker. Propargyl-PEG3-acid is also a PEG-based PROTAC linker used to synthesize 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA and Propargyl-PEG3-acid[1]. |
| In vitro | ADCs, or antibody-drug conjugates, consist of an antibody that is linked to a cytotoxic drug molecule via a specialized linker. This allows the antibody to specifically target certain cells or proteins, while the attached cytotoxin can selectively destroy those targeted cells. PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E6 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation. |
| Molecular Weight | 216.23 |
| Formula | C10H16O5 |
| Cas No. | 1347760-82-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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