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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | Inquiry | 7-10 days | |
500 mg | Inquiry | 7-10 days |
Description | Propargyl-PEG2-amine is a non-cleavable ADC linker employed for synthesizing antibody-drug conjugates (ADCs). It is a PEG-based PROTAC linker that finds applications in PROTAC synthesis [1][2]. |
In vitro | ADCs, or antibody-drug conjugates, consist of an antibody that is linked to a cytotoxic drug molecule via a specialized linker. This allows the antibody to specifically target certain cells or proteins, while the attached cytotoxin can selectively destroy those targeted cells. PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E4 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation. |
Molecular Weight | 143.18 |
Formula | C7H13NO2 |
Cas No. | 944561-44-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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