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4-Succinimidyl-oxycarbonyl-α-(2-pyridyldithio)toluene
Catalog No. T39070Cas No. 160854-54-6
4-Succinimidyl-oxycarbonyl-α-(2-pyridyldithio)toluene is a non-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs).
4-Succinimidyl-oxycarbonyl-α-(2-pyridyldithio)toluene
Catalog No. T39070Cas No. 160854-54-6
4-Succinimidyl-oxycarbonyl-α-(2-pyridyldithio)toluene is a non-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs).
| Pack Size | Price | Availability | Quantity |
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| 100 mg | Inquiry | Backorder | |
| 500 mg | Inquiry | Backorder |
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Succinic anhydride is a cyclic anhydride. Succinic anhydride acts as a nonclaevable ADC linker. Succinic anhydride can react with compound 4 to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.
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Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.
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DSG Crosslinker
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DSG Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).
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DSS Crosslinker
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DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is a homobifunctional crosslinker that is cell membrane permeable, with amine-reactive NHS esters at both ends of an 8-atom [11.4 angstrom] spacer arm for conjugating proteins, including intracellular proteins.
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Fmoc-Gly-Gly-OH
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Fmoc-Gly-Gly-OH, a cleavable ADC linker, can be used in the synthesis of antibody-drug conjugates (ADCs).
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Boc-NH-PEG4-CH2COOH
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Boc-NH-PEG4-CH2COOH is a cleavable ADC linker utilized in the development of antibody-drug conjugates (ADC)[1].
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Val-cit-PAB-OH is an ADC linker that is cleavable.
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FMoc-Val-Cit-PAB-PNP
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Fmoc-Val-Cit-PAB-PNP is a linker used in Antibody-Drug Conjugation (ADC).
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N-Boc-PEG5-bromide
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N-Boc-PEG5-bromide is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and serves as a PROTAC linker based on PEG and Alkyl/ether.
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Product Introduction
Bioactivity
Chemical Properties
| Description | 4-Succinimidyl-oxycarbonyl-α-(2-pyridyldithio)toluene is a non-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). |
| In vitro | Antibody-drug conjugates (ADCs) consist of an antibody linked to a cytotoxic agent via an ADC linker[1]. |
| Molecular Weight | 374.43 |
| Formula | C17H14N2O4S2 |
| Cas No. | 160854-54-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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