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Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $41 | In Stock | |
25 mg | $58 | In Stock | |
50 mg | $74 | In Stock | |
100 mg | $97 | In Stock | |
200 mg | $162 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively. |
In vitro | Sulfo-SMCC, a crosslinker featuring a maleimide group and an N-hydroxysuccinimide ester, is designed to attach to sulfhydryl groups and primary amines, respectively. It effectively prevents the longitudinal fusion of stabilized Microtubules (MTs), which retain a consistent mean length regardless of incubation duration. This has been demonstrated in experiments where MTs, upon treatment with 250 μM Sulfo-SMCC, were observed at intervals of 0 hours, 6 hours, and 24 hours, showing no change in length over time[1]. |
Molecular Weight | 436.37 |
Formula | C16H17N2NaO9S |
Cas No. | 92921-24-9 |
Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 12 mg/mL (27.50 mM), Sonication is recommended. DMSO: 125 mg/mL (286.45 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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