Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Sulfo-SMCC sodium

Catalog No. T18728Cas No. 92921-24-9

Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively.

Sulfo-SMCC sodium

Sulfo-SMCC sodium

Purity: 99.9%
Catalog No. T18728Cas No. 92921-24-9
Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively.
Pack SizePriceAvailabilityQuantity
10 mg$41In Stock
25 mg$58In Stock
50 mg$74In Stock
100 mg$97In Stock
200 mg$162In Stock
1 mL x 10 mM (in DMSO)$50In Stock
Bulk & Custom
Add to Cart
Questions
View More
Select Batch
Purity:99.9%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively.
In vitro
Sulfo-SMCC, a crosslinker featuring a maleimide group and an N-hydroxysuccinimide ester, is designed to attach to sulfhydryl groups and primary amines, respectively. It effectively prevents the longitudinal fusion of stabilized Microtubules (MTs), which retain a consistent mean length regardless of incubation duration. This has been demonstrated in experiments where MTs, upon treatment with 250 μM Sulfo-SMCC, were observed at intervals of 0 hours, 6 hours, and 24 hours, showing no change in length over time[1].
Chemical Properties
Molecular Weight436.37
FormulaC16H17N2NaO9S
Cas No.92921-24-9
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 12 mg/mL (27.50 mM), Sonication is recommended.
DMSO: 125 mg/mL (286.45 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.2916 mL11.4582 mL22.9163 mL114.5817 mL
5 mM0.4583 mL2.2916 mL4.5833 mL22.9163 mL
10 mM0.2292 mL1.1458 mL2.2916 mL11.4582 mL
20 mM0.1146 mL0.5729 mL1.1458 mL5.7291 mL
DMSO
1mg5mg10mg50mg
50 mM0.0458 mL0.2292 mL0.4583 mL2.2916 mL
100 mM0.0229 mL0.1146 mL0.2292 mL1.1458 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Sulfo-SMCC sodium | purchase Sulfo-SMCC sodium | Sulfo-SMCC sodium cost | order Sulfo-SMCC sodium | Sulfo-SMCC sodium chemical structure | Sulfo-SMCC sodium in vitro | Sulfo-SMCC sodium formula | Sulfo-SMCC sodium molecular weight