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Description | Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker employed for the synthesis of PROTACs[1]. It is also a non-cleavable 2 unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[2]. |
In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
Alias | N3-PEG2-CH2CH2NH2 |
Molecular Weight | 174.2 |
Formula | C6H14N4O2 |
Cas No. | 166388-57-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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