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N-Succinimidyl 3-(Bromoacetamido)propionate
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Catalog No. T16250Cas No. 57159-62-3
Alias 3-(2-Bromoacetamido)propanoic acid NHS ester
N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker used in the synthesis of PROTACs and antibody-drug conjugates (ADCs) [1, 2], serving as a cleavable ADC linker to facilitate drug-antibody conjugation for targeted delivery [2].
N-Succinimidyl 3-(Bromoacetamido)propionate
😃Good
Catalog No. T16250Alias 3-(2-Bromoacetamido)propanoic acid NHS esterCas No. 57159-62-3
N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker used in the synthesis of PROTACs and antibody-drug conjugates (ADCs) [1, 2], serving as a cleavable ADC linker to facilitate drug-antibody conjugation for targeted delivery [2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | Inquiry | 7-10 days | |
| 500 mg | Inquiry | 7-10 days |
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View MoreInhibitors Related to "N-Succinimidyl 3-(Bromoacetamido)propionate"
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Succinic anhydride is a cyclic anhydride. Succinic anhydride acts as a nonclaevable ADC linker. Succinic anhydride can react with compound 4 to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.
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Boc-C16-COOH
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Boc-C16-COOH is a alkyl-chain-based PROTAC linker. Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Fmoc-8-amino-3,6-dioxaoctanoic acid
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Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.
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DSG Crosslinker
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DSG Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).
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Fmoc-Gly-Gly-OH
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Fmoc-Gly-Gly-OH, a cleavable ADC linker, can be used in the synthesis of antibody-drug conjugates (ADCs).
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SMCC
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SMCC (N-Succinimidyl 4-(N-maleimidomethyl)cycl) is a heterobifunctional protein crosslinker.
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DSS Crosslinker
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EMCS
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Boc-NH-PEG4-CH2COOH
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Boc-NH-PEG4-CH2COOH is a cleavable ADC linker utilized in the development of antibody-drug conjugates (ADC)[1].
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N-Boc-PEG5-bromide
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N-Boc-PEG5-bromide is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and serves as a PROTAC linker based on PEG and Alkyl/ether.
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DSP Crosslinker
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DSP Crosslinker, used in antibody-drug conjugates (ADCs) synthesis, is a cleavable ADC linker[1].
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CitedBoc-Val-Cit-OH
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Boc-Val-Cit-OH is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).
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Product Introduction
Bioactivity
Chemical Properties
| Description | N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker used in the synthesis of PROTACs and antibody-drug conjugates (ADCs) [1, 2], serving as a cleavable ADC linker to facilitate drug-antibody conjugation for targeted delivery [2]. |
| In vitro | PROTACs contain two ligands joined by a linker: one binds to an E3 ubiquitin ligase, and the other to the target protein, utilizing the ubiquitin-proteasome system to selectively degrade target proteins [1]. ADCs consist of an antibody linked to an ADC cytotoxin through an ADC linker [2]. |
| Alias | 3-(2-Bromoacetamido)propanoic acid NHS ester |
| Molecular Weight | 307.1 |
| Formula | C9H11BrN2O5 |
| Cas No. | 57159-62-3 |
| Relative Density. | 1.69 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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