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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $29 | In Stock |
Description | NH2-PEG6-Boc is a PEG-based PROTAC linker used in PROTAC synthesis[1] and a non-cleavable 6-unit PEG ADC linker for antibody-drug conjugates (ADCs) synthesis[2]. |
In vitro | PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E3 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation. |
Molecular Weight | 409.51 |
Formula | C19H39NO8 |
Cas No. | 1286281-32-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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