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DACN(Tos2,6-OH)
Catalog No. T87926Cas No. 2109751-74-6
DACN(Tos2,6-OH) serves as a potent click chemistry reagent featuring an Azide group and a distinctively bent alkyne moiety. This structure enhances its reactivity for cycloaddition reactions compared to nonbent acyclic alkynes, especially evident in cyclononyne alkynes which exhibit substantially higher reactivity. The bent configuration adds both electronic and steric effects that intensify the reactivity, facilitating strain-promoted azide-alkyne cycloaddition (SPAAC). SPAAC with cycloalkynes is commonly utilized for dependable molecular conjugation across various fields. Furthermore, DACN(Tos2,6-OH) can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), coupling efficiently with molecules that contain Azide groups. Compared to cyclooctynes, DACNs demonstrate superior thermal and chemical stabilities while maintaining similar click reactivity [1]. Nitrogens within the compound provide versatile linking sites for numerous functional units.
DACN(Tos2,6-OH)
Catalog No. T87926Cas No. 2109751-74-6
DACN(Tos2,6-OH) serves as a potent click chemistry reagent featuring an Azide group and a distinctively bent alkyne moiety. This structure enhances its reactivity for cycloaddition reactions compared to nonbent acyclic alkynes, especially evident in cyclononyne alkynes which exhibit substantially higher reactivity. The bent configuration adds both electronic and steric effects that intensify the reactivity, facilitating strain-promoted azide-alkyne cycloaddition (SPAAC). SPAAC with cycloalkynes is commonly utilized for dependable molecular conjugation across various fields. Furthermore, DACN(Tos2,6-OH) can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), coupling efficiently with molecules that contain Azide groups. Compared to cyclooctynes, DACNs demonstrate superior thermal and chemical stabilities while maintaining similar click reactivity [1]. Nitrogens within the compound provide versatile linking sites for numerous functional units.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | DACN(Tos2,6-OH) serves as a potent click chemistry reagent featuring an Azide group and a distinctively bent alkyne moiety. This structure enhances its reactivity for cycloaddition reactions compared to nonbent acyclic alkynes, especially evident in cyclononyne alkynes which exhibit substantially higher reactivity. The bent configuration adds both electronic and steric effects that intensify the reactivity, facilitating strain-promoted azide-alkyne cycloaddition (SPAAC). SPAAC with cycloalkynes is commonly utilized for dependable molecular conjugation across various fields. Furthermore, DACN(Tos2,6-OH) can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), coupling efficiently with molecules that contain Azide groups. Compared to cyclooctynes, DACNs demonstrate superior thermal and chemical stabilities while maintaining similar click reactivity [1]. Nitrogens within the compound provide versatile linking sites for numerous functional units. |
| Molecular Weight | 448.56 |
| Formula | C21H24N2O5S2 |
| Cas No. | 2109751-74-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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