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Z-AEVD-FMK

Name: Z-AEVD-FMK
Brand: TargetMol
SKU: T36331
Rating: 4.5 (1 reviews)

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Catalog No. T36331Cas No. 1135688-47-9

Alias Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone

Z-AEVD-FMK (Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone) is a degradable ADC linker and caspase-10 inhibitor, reducing TNF-α/butyrate-induced apoptosis, and inhibiting Gal-9-induced apoptosis.

Z-AEVD-FMK

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Catalog No. T36331Alias Z-Ala-Glu-Val-Asp-Fluoromethyl KetoneCas No. 1135688-47-9

Z-AEVD-FMK (Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone) is a degradable ADC linker and caspase-10 inhibitor, reducing TNF-α/butyrate-induced apoptosis, and inhibiting Gal-9-induced apoptosis.

Pack Size	Price	Availability
500 μg	$170	35 days
1 mg	$325	35 days
5 mg	$1,420	35 days

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Z-AEVD-FMK (Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone) is a degradable ADC linker and caspase-10 inhibitor, reducing TNF-α/butyrate-induced apoptosis, and inhibiting Gal-9-induced apoptosis.
In vitro	Z-AEVD-FMK (10 μM) inhibited anti-FAS Ab and TNF-α induced apoptosis. [1]
Alias	Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone

Chemical Properties

Molecular Weight	610.63
Formula	C₂₈H₃₉FN₄O₁₀
Cas No.	1135688-47-9
Smiles	[C@H](C(N[C@H](C(N[C@@H](CC(OC)=O)C(CF)=O)=O)C(C)C)=O)(NC([C@@H](NC(OCC1=CC=CC=C1)=O)C)=O)CCC(OC)=O

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (163.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6377 mL	8.1883 mL	16.3765 mL	81.8826 mL
5 mM	0.3275 mL	1.6377 mL	3.2753 mL	16.3765 mL
10 mM	0.1638 mL	0.8188 mL	1.6377 mL	8.1883 mL
20 mM	0.0819 mL	0.4094 mL	0.8188 mL	4.0941 mL
50 mM	0.0328 mL	0.1638 mL	0.3275 mL	1.6377 mL
100 mM	0.0164 mL	0.0819 mL	0.1638 mL	0.8188 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc