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2,2-Oxybis(ethylamine) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | Inquiry | In Stock | |
500 mg | Inquiry | In Stock |
Description | 2,2-Oxybis(ethylamine) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |
In vitro | PROTACs consist of two distinct ligands joined by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets the specific protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
Molecular Weight | 104.15 |
Formula | C4H12N2O |
Cas No. | 2752-17-2 |
Smiles | NCCOCCN |
Relative Density. | 0.97 (corresponds to D4(20)). Temperature:20 °C. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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