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Fmoc-PEG12-NHS ester
🥰Excellent
Catalog No. T17978Cas No. 2227246-92-4
Fmoc-PEG12-NHS ester, a PEG-based linker for PROTACs, facilitates the joining of two essential ligands, crucial for the formation of PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Fmoc-PEG12-NHS ester
🥰Excellent
Catalog No. T17978Cas No. 2227246-92-4
Fmoc-PEG12-NHS ester, a PEG-based linker for PROTACs, facilitates the joining of two essential ligands, crucial for the formation of PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $39 | In Stock | |
| 10 mg | $55 | In Stock | |
| 25 mg | $89 | In Stock | |
| 50 mg | $139 | In Stock | |
| 100 mg | $208 | In Stock |
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6-Maleimidocapronic acid
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6-Maleimidocapronic acid, an alkyl chain-based PROTAC linker, is utilized in the synthesis of PROTACs (proteolysis-targeting chimeras).
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11-Aminoundecanoic acid
T173232432-99-7
11-Aminoundecanoic acid, an alkyl chain-based PROTAC linker, is employed in PROTAC synthesis.
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1,3-Dibromo-5,5-dimethylhydantoin
DBDMH
T1732177-48-5
1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.
- $29
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Diethylene glycol bis(p-toluenesulfonate)
Diethylene glycol di(p-toluenesulfonate), Bis-Tos-PEG2
T178237460-82-4
Diethylene glycol bis(p-toluenesulfonate) (Bis-Tos-PEG2) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
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Fmoc-8-amino-3,6-dioxaoctanoic acid
Fmoc-NH-PEG2-CH2COOH
T15304166108-71-0
Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.
- $29
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1-Bromo-6-chlorohexane
Hexane, 1-bromo-6-chloro-, 6-Chlorohexyl bromide, 6-Bromohexyl Chloride, 1-Chloro-6-bromohexane
T407286294-17-3
1-Bromo-6-chlorohexane (Hexane, 1-bromo-6-chloro-) is used as PROTAC linker.
- $35
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Pentaethylene glycol
3,6,9,12-Tetraoxatetradecane-1,14-diol
T164684792-15-8
Pentaethylene glycol (3,6,9,12-Tetraoxatetradecane-1,14-diol) is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
- $29
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Bis-Tos-PEG4
Tetraethylene glycol di(p-toluenesulfonate), PROTAC Linker 16, 1,11-Bis(tosyloxy)-3,6,9-trioxaundecane
T1861437860-51-8
Bis-Tos-PEG4 (PROTAC Linker 16) is a PEG-based linker utilized in the synthesis of PROTACs.
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Decaethylene glycol
HO-PEG10-OH
T150895579-66-8
Decaethylene glycol (HO-PEG10-OH) is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
- $36
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5-Ethynyl-2'-deoxyuridine
Cited
T1734161135-33-9
5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.
- $33
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CitedAc4ManNAz
T14093361154-30-5In house
Ac4ManNAz is an azide-containing metabolic glycoprotein labeling reagent that can selectively modify proteins and can be used for cell labeling, tracking, and proteomic analysis.
- $32
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N-Boc-4-pentyne-1-amine
T18391151978-50-6
N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound used in the synthesis of PROTAC MG-277 [1].
- $29
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Fmoc-PEG12-NHS ester, a PEG-based linker for PROTACs, facilitates the joining of two essential ligands, crucial for the formation of PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |
| In vitro | PROTACs consist of two ligands linked together: one binds to an E3 ubiquitin ligase, and the other targets a specific protein. These compounds utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| Molecular Weight | 937.03 |
| Formula | C46H68N2O18 |
| Cas No. | 2227246-92-4 |
| Smiles | C(OC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O)=O)C2C=3C(C=4C2=CC=CC4)=CC=CC3 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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