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PIK5-12d
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Catalog No. T79668
PIK5-12d is a PROTAC PIKfyve degrader with antitumor activity that induces massive cytoplasmic vacuolization and blocks autophagic flow. PIK5-12d inhibits the value-added of cancer cells and can be used in the study of prostate cancer.
PIK5-12d
😃Good
Purity: 99.90%
Catalog No. T79668
PIK5-12d is a PROTAC PIKfyve degrader with antitumor activity that induces massive cytoplasmic vacuolization and blocks autophagic flow. PIK5-12d inhibits the value-added of cancer cells and can be used in the study of prostate cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $398 | In Stock | |
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Purity:99.90%
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Product Introduction
Bioactivity
Chemical Properties
| Description | PIK5-12d is a PROTAC PIKfyve degrader with antitumor activity that induces massive cytoplasmic vacuolization and blocks autophagic flow. PIK5-12d inhibits the value-added of cancer cells and can be used in the study of prostate cancer. |
| Targets&IC50 | PIKfyve:1.48 nM (DC50) |
| In vitro | PIK5-12d is a PROTAC PIKfyve degrader with a DC50 of 1.48 nM.PIK5-12d triggers massive cytoplasmic vacuolization and inhibits autophagic flow in a wide range of prostate cancer cells, thereby inhibiting the proliferation of prostate cancer cells. [1] |
| Molecular Weight | 973.19 |
| Formula | C52H64N10O7S |
| Smiles | CC1=CC=CC(/C=N/NC2=NC(OCCC3=CC=C(NC(CCCCC(N[C@H](C(N4C[C@H](O)C[C@H]4C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)C(C)(C)C)=O)=O)C=C3)=NC(N7CCOCC7)=C2)=C1 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 160 mg/mL (164.41 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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