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(S,R,S)-AHPC-PEG4-N3

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Purity:98.06%

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COA HPLC HNMR

(S,R,S)-AHPC-PEG4-N3

Catalog No. T17921Cas No. 1797406-81-5

(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both commonly employed in PROTAC technology.

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Pack Size	Price	Availability
1 mg	$30	In Stock
2 mg	$40	In Stock
5 mg	$64	In Stock
10 mg	$93	In Stock
25 mg	$156	In Stock
50 mg	$255	In Stock
100 mg	$455	In Stock

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Product Introduction

Bioactivity

Description	(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both commonly employed in PROTAC technology.
In vitro	E3 ligase Ligand-Linker Conjugates 4 together with JQ1 triggers the intracellular destruction of BET proteins[1].
Alias	VH032-PEG4-N3, VHL Ligand-Linker Conjugates 5, E3 ligase Ligand-Linker Conjugates 4

Chemical Properties

Molecular Weight	689.83
Formula	C32H47N7O8S
Cas No.	1797406-81-5

Storage & Solubility Information

Storage

keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (65.2 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4496 mL	7.2482 mL	14.4963 mL	72.4816 mL
5 mM	0.2899 mL	1.4496 mL	2.8993 mL	14.4963 mL
10 mM	0.1450 mL	0.7248 mL	1.4496 mL	7.2482 mL
20 mM	0.0725 mL	0.3624 mL	0.7248 mL	3.6241 mL
50 mM	0.0290 mL	0.1450 mL	0.2899 mL	1.4496 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc