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NH2-PEG2-C6-Cl

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COA HNMR

NH2-PEG2-C6-Cl

Catalog No. T40858Cas No. 744203-60-9

NH2-PEG2-C6-Cl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

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Pack Size	Price	Availability
5 mg	$33	Backorder
10 mg	$47	Backorder
25 mg	$77	Backorder
50 mg	$115	Backorder
100 mg	$182	Backorder
200 mg	$271	Backorder

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Product Introduction

Bioactivity

Description	NH2-PEG2-C6-Cl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
In vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1] .
Alias	NH2-PEG2-C6-Cl

Chemical Properties

Molecular Weight	223.74
Formula	C10H22ClNO2
Cas No.	744203-60-9

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (402.3 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4695 mL	22.3474 mL	44.6947 mL	223.4737 mL
5 mM	0.8939 mL	4.4695 mL	8.9389 mL	44.6947 mL
10 mM	0.4469 mL	2.2347 mL	4.4695 mL	22.3474 mL
20 mM	0.2235 mL	1.1174 mL	2.2347 mL	11.1737 mL
50 mM	0.0894 mL	0.4469 mL	0.8939 mL	4.4695 mL
100 mM	0.0447 mL	0.2235 mL	0.4469 mL	2.2347 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc