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Pyrroline-5-carboxylate sodium

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Catalog No. T88439Cas No. 72978-16-6

Pyrroline-5-carboxylate sodium is a naturally occurring intermediate and a potent activator of redox-dependent metabolic pathways and a PROTAC linker.

Pyrroline-5-carboxylate sodium

Pyrroline-5-carboxylate sodium

🥰Excellent
Catalog No. T88439Cas No. 72978-16-6
Pyrroline-5-carboxylate sodium is a naturally occurring intermediate and a potent activator of redox-dependent metabolic pathways and a PROTAC linker.
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Product Introduction

Bioactivity
Description
Pyrroline-5-carboxylate sodium is a naturally occurring intermediate and a potent activator of redox-dependent metabolic pathways and a PROTAC linker.
In vitro
Arabidopsis mutant plants deficient in Pyrroline-5-carboxylate catabolism exhibited a cell death-like response (HR) when grown in media containing exogenous Pyrroline-5-carboxylate sodium or proline. Similarly, under oxidative stress conditions, yeast and plant cells showed increased reactive oxygen species (ROS) production and programmed cell death (PCD) due to elevated Pyrroline-5-carboxylate levels. [1]
Chemical Properties
Molecular Weight135.1
FormulaC5H6NNaO2
Cas No.72978-16-6
SmilesO=C(C1=NCCC1)[O-].[Na+]
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 20 mg/mL (148.04 mM.), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM7.4019 mL37.0096 mL74.0192 mL370.0962 mL
5 mM1.4804 mL7.4019 mL14.8038 mL74.0192 mL
10 mM0.7402 mL3.7010 mL7.4019 mL37.0096 mL
20 mM0.3701 mL1.8505 mL3.7010 mL18.5048 mL
50 mM0.1480 mL0.7402 mL1.4804 mL7.4019 mL
100 mM0.0740 mL0.3701 mL0.7402 mL3.7010 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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