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cyclo(RLsKDK) TFA

Name: cyclo(RLsKDK) TFA
Brand: TargetMol
SKU: T75998
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T75998

Alias BK-1361 TFA, BK1361 TFA

Cyclo(RLsKDK) TFA (BK-1361 TFA) is a cyclic peptide and selective ADAM8 metalloproteinase inhibitor, used in research on inflammation and cancer.

cyclo(RLsKDK) TFA

🥰Excellent

Purity: 98.54%

Catalog No. T75998Alias BK-1361 TFA, BK1361 TFA

Cyclo(RLsKDK) TFA (BK-1361 TFA) is a cyclic peptide and selective ADAM8 metalloproteinase inhibitor, used in research on inflammation and cancer.

Pack Size	Price	Availability	Quantity
5 mg	$880	In Stock

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Purity:98.54%

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Cyclo(RLsKDK) TFA (BK-1361 TFA) is a cyclic peptide and selective ADAM8 metalloproteinase inhibitor, used in research on inflammation and cancer.
Targets&IC50	ADAM8:182 nM
In vitro	cyclo(RLsKDK) TFA promoted ADAM8 inhibition and CD23 shedding with IC50 values of 120 nM and 182 nM, respectively. cyclo(RLsKDK) TFA (200 nM,0-12h) increased the activity of pro-ADAM8 [2]. cyclo(RLsKDK) TFA (200 nM/500 nM,12 h) promoted the growth of Panc1_ctrl and Panc1_A8 cells. cyclo(RLsKDK) TFA(500 nM) causes ERK1/2 phosphorylation in Panc1_ctrl and Panc1_A8 cells. [1]
In vivo	cyclo(RLsKDK) TFA (10 μg/g once a week for 4 weeks) significantly reduced tumor volume in mice xenografted with Panc1_ctrl and Panc1_A8. [1]
Alias	BK-1361 TFA, BK1361 TFA

Chemical Properties

Molecular Weight	841.88
Formula	C₃₃H₅₈F₃N₁₁O₁₁
Smiles	CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN=C(N)N)CCCCN)CC(=O)O)CCCCN)CO.C(=O)(C(F)(F)F)O

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 80 mg/mL (95.03 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.1878 mL	5.9391 mL	11.8782 mL	59.3909 mL
5 mM	0.2376 mL	1.1878 mL	2.3756 mL	11.8782 mL
10 mM	0.1188 mL	0.5939 mL	1.1878 mL	5.9391 mL
20 mM	0.0594 mL	0.2970 mL	0.5939 mL	2.9695 mL
50 mM	0.0238 mL	0.1188 mL	0.2376 mL	1.1878 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

cyclo(RLsKDK) TFA

cyclo(RLsKDK) TFA

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