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Obexelimab
Catalog No. T81624Cas No. 1690307-05-1
Alias XmAb5871, AMG729, AMG 729
Obexelimab (XmAb5871) is a bifunctional monoclonal antibody that binds CD19 and FcyRIIb, inhibits B-cells, plasmoblasts, and plasma cells, and may be used in the study of autoimmune diseases such as systemic lupus erythematosus.
Obexelimab
Obexelimab
Catalog No. T81624Alias XmAb5871, AMG729, AMG 729Cas No. 1690307-05-1
Obexelimab (XmAb5871) is a bifunctional monoclonal antibody that binds CD19 and FcyRIIb, inhibits B-cells, plasmoblasts, and plasma cells, and may be used in the study of autoimmune diseases such as systemic lupus erythematosus.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $723 | In Stock | |
| 10 mg | $986 | In Stock | |
| 25 mg | $1,490 | In Stock | |
| 50 mg | $1,970 | In Stock |
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Concentration:6.29 mg/mL
Purity:95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Obexelimab (XmAb5871) is a bifunctional monoclonal antibody that binds CD19 and FcyRIIb, inhibits B-cells, plasmoblasts, and plasma cells, and may be used in the study of autoimmune diseases such as systemic lupus erythematosus. |
| In vitro | Obexelimab induces the expression of genes associated with the apoptotic pathway and promotes apoptosis in B cells. [1] 10 μg/mL Obexelimab, treated for 3 min, inhibited B cell activation and its function by inhibiting BCR-mediated calcium influx and promoting phosphorylation of FcγRIIb. [2] |
| In vivo | 10 mg/kg Obexelimab, injected intraperitoneally twice weekly, suppressed autoimmune responses in immunodeficient mice implanted with peripheral blood mononuclear cells (PBMC) from rheumatoid arthritis (RA) patients. [2] |
| Alias | XmAb5871, AMG729, AMG 729 |
| Cas No. | 1690307-05-1 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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