Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

ZLDI-8

Catalog No. T13410Cas No. 667880-38-8

ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.

ZLDI-8

ZLDI-8

Purity: 98.09%
Catalog No. T13410Cas No. 667880-38-8
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
Pack SizePriceAvailabilityQuantity
1 mg$52In Stock
5 mg$123In Stock
10 mg$198In Stock
25 mg$372In Stock
50 mg$596In Stock
100 mg$953In Stock
1 mL x 10 mM (in DMSO)$135In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "ZLDI-8"

Select Batch
Purity:98.09%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
Targets&IC50
ADAM17:31.6 μM , Tyrosine phosphatase:, Tyrosine phosphatase:(ki)26.22 μM
In vitro
ZLDI-8;?it inhibited the cleavage of NOTCH protein, consequently decreased the expression of pro-survival/anti-apoptosis and EMT related proteins.?ZLDI-8 treatment enhanced the susceptibility of HCC cells to a small molecular kinase inhibitor Sorafenib, and chemotherapy agents Etoposide and Paclitaxel.?ZLDI-8 treatment enhanced the effect of Sorafenib on inhibiting tumor growth in nude HCC-bearing mice model[1].
In vivo
In nude HCC-bearing mice model, ZLDI-8 (0.2-2 mg/kg; intraperitoneal injection; every two days; for 20 days; nude mice) treatment enhances the effect of Sorafenib on inhibiting tumor growth [1].
Chemical Properties
Molecular Weight433.52
FormulaC24H23N3O3S
Cas No.667880-38-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 62.5 mg/mL (144.17 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3067 mL11.5335 mL23.0670 mL115.3349 mL
5 mM0.4613 mL2.3067 mL4.6134 mL23.0670 mL
10 mM0.2307 mL1.1533 mL2.3067 mL11.5335 mL
20 mM0.1153 mL0.5767 mL1.1533 mL5.7667 mL
50 mM0.0461 mL0.2307 mL0.4613 mL2.3067 mL
100 mM0.0231 mL0.1153 mL0.2307 mL1.1533 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy ZLDI-8 | purchase ZLDI-8 | ZLDI-8 cost | order ZLDI-8 | ZLDI-8 chemical structure | ZLDI-8 in vivo | ZLDI-8 in vitro | ZLDI-8 formula | ZLDI-8 molecular weight